Interns in this geographically-distributed REU program have the opportunity to participate in research using the Rosetta Commons software. The Rosetta Commons software suite includes algorithms for computational modeling and analysis of protein structures. It has enabled notable scientific advances in computational biology, including de novo protein design, enzyme design, ligand docking, and structure prediction of biological macromolecules and macromolecular complexes.

Students learn the inner details of the PyRosetta and community coding environment. Students research in a molecular modeling and design laboratory, developing new algorithms and discovering new science. Interns are mentored by faculty and graduate interns. 

The Program:

• One week of Rosetta Code School, where you will learn the inner details of the Rosetta C++ code and community coding environment, so you are fully prepared for the summer!
• 8 weeks of hands-on research in a molecular modeling and design laboratory, developing new algorithms and discovering new science.
• The summer will finish with a trip to the Rosetta Conference, where you will present your research in a poster and connect with Rosetta developers from around the world. The sponsor, NSF, will provide housing, travel expenses, and a stipend.

Projects include:

• “Designing new protein switches for synthetic biology applications”
• "Antibody engineering by deep learning "
• “Designing small-molecules that break down cancer-driving protein”
• “Design of novel transposases for scarless DNA-insertion using Rosetta”
• “De Novo Protein Design for Immunotherapeutics”
• “Design of Dengue Virus Subunit Vaccines”
• “Applying high-throughput experimental data to guide computational protein design”

…and many more